Associations with severity of FPIES reactions
123 children (73%) experienced at least one severe FPIES reaction, having all 3 cardinal features of FPIES (vomiting with lethargy, floppiness and pallor). All 40 infants requiring IV fluid administration met criteria for a severe reaction. Vaginal delivery (OR=0.4, CI=0.2-1.2, P =0.097) and an increased duration of breastfeeding (OR=0.9 per month, CI=0.8-1.0, P =0.05) appeared to be negatively associated with experiencing a severe FPIES reaction. No particular food group or other factors were associated with an increased risk of a severe FPIES reaction (Figure 1).