RGD

RGD peptides are common ligands used for the delivery of siRNA into cervical cancer cells due to the fact that they are directly related to cancer angiogenesis and metabolism of quick-proliferating pancreatic tumor cells. The RGD peptide can robustly and selectively interact with overexpressed receptors of αvβ5 and αvβ3 integrins on pancreatic cancer cells (Y. Sun et al., 2017). Kim et al . (H. A. Kim, Nam, & Kim, 2014) designed PA-PEG1k-RGD to deliver VEGF siRNA in PANC-1 cells. The PA-PEG1k-RGD/VEGF siRNA complexes showed higher cellular uptake and gene silencing than non-targeted ones.