Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer. Table 3. Examples of siRNA-based combination therapies for pancreatic cancer.
Delivery vehicle Targeted gene Anticancer drug In vitro In vivo Route of administration Cell line Mouse models Ref.
Third generation poly(propylenimine) dendrimers (DAB-Am16) ITCH Gemcitabine + + iv. MIA PaCa-2 and PANC-1 Mice bearing MIA PaCa-2 xenografts (de la Fuente et al., 2015)
scFvCD44V6- functionalized Iron oxide nanoparticles (NPs)-PEI Bmi-1 Gemcitabine + + iv. (tail vein injection) PANC-1 Mouse model bearing subcutaneous human PANC-1 xenografts (Li et al., 2016)
polyethyleneimine (PEI) CUX1 Gemcitabine and 5-FU + + Intratumoral PANC-1 Mice model bearing subcutaneous human CAPAN-1 xenografts (Ripka et al., 2010)
pegylated cationic liposomes (PCat) survivin Paclitaxel - + ip. - Mice model human pancreatic Hs766T xenograft tumor (J. Wang et al., 2015)
Poly(ethylene glycol)-block-poly(l-lysine) for siRNA and poly(ethylene glycol)-block-poly(dl-lactide) for arsenic K-ras Arsenic + - - PANC-1 and BXPC-3 - (Zeng et al., 2014)
Lipid-polymer hybrid nanoparticles (LENPs) HIF1α Gemcitabine + + iv. (tail vein injection) PANC-1 Female BALB/C nude mice model bearing subcutaneous human PANC-1 xenografts (X. Zhao et al., 2015)
Polyelectrolyte polymers coated Gold nanorods (AuNRs); therapeutic agents can be released after irradiating with 665 nm light K-ras Doxorubicin + + Intratumoral PANC-1 Mouse model bearing subcutaneous human PANC-1 xenografts (Yin et al., 2015)
Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection Abbreviation: iv.: Intravenous injection; ip.: Intraperitoneal injection