Gastrin

Gastrin tends to interact with the overexpressed cholecystokinin-B (CCK-B) receptor with a high affinity in various types of pancreatic cancer cells (Banerjee & Saluja, 2018). Therefore, to target gastrin mRNA in pancreatic cancer cells, some researchers use gastrin-mediated delivery. In one of these studies, gastrin-polyethylene glycol-poly(L-lysine) (Ga-[PEG]5k-PLL27) has been designed by Burks and his co-workers (Burks et al., 2018) to deliver gastrin siRNA into the pancreatic tumor cells. The Ga-conjugated carrier revealed greater gene silencing of gastrin in PANC-1 cells than unmodified ones.