Graphene oxide
nanomaterials
Graphene oxide (GO), a common derivative of graphene, is an exciting
nanomaterial that possesses several physical properties, which make it
suitable for biomedical applications. GO is water-soluble providing
large platform for convenient functionalization, and it exhibits
fluorescent emission in near-infrared (NIR) to the visible spectrum
(Maiti, Tong, Mou, & Yang, 2019). Yin et al . (Yin et al., 2017)
proposed a multi-functionalized monolayer system by folic acid (FA) and
Poly-allylamine hydrochloride (PAH) conjugation onto GO nanosheets. This
allows for dual gene silencing in pancreatic cancer cells (MIA PaCa-2).
It was ascertained that HDAC1 and K-ras , two genes
essential for cell growth, were silenced simultaneously and the
transfection efficiency was over 90%. Furthermore, as a result of the
synergic combination of gene silencing and photothermal activity of GO
under NIR light, in vivo cell proliferation was inhibited by
>80%. The system exhibited low toxicity and may serve as a
highly biocompatible nanocarrier for biomedical applications.