Table 1 shows the summary data for the variants that proxy IL-6 signalling inhibition. SNP: single nucleotide polymorphism. Beta is the unit change in natural log transformed CRP (mg/L) per copy increment in the effect allele. R2 represents the variance in CRP explained by the respective genetic variant. F-statistic measures the strength of the instrumental variable with the exposure. Variants identified and associated well with IL-6 signalling inhibition in a previous Mendelian randomization study exploring IL-6 inhibition and effects on ischaemic stroke and cardiovascular outcomes.8