Limitations
The retrospective, nonrandomized, single-centre design of our study has
some limitations. Because the CM group comprised the initial patients
who underwent LAAC, there might have been a learning curve, which would
be in favour of the MM group. However, PT events occurred in the
110th and 174th patients in the MM
group. This finding suggests there was no significant correlation
between the incidence of PE/PT and the learning curve. Additionally, the
limited number of events limited the power for our ability to detect a
significant association, as shown by the wide confidence intervals.