Main Outcomes
In this observational cohort study
(after PSM), the incidence of PE was 4.68% in the LDA group, while in
the control group (vs. 9.79%), and LDA showed a significant
reduction of PE (OR:0.48, 95% CI:
0.24-0.95, p =0.048). While the risk of gestational hypertension
was not reduced by LDA (OR:0.88, 95% CI: 0.45-1.73, p =0.855).
The median of the gestational length of the pregnancy (in days) was
larger in the LDA group than in controls (259 vs. 254,p <0.001). Moreover, the occurrence of PTB was also significantly
reduced in the LDA group compare to the control group (7.66% vs.15.32%, OR: 0.50, 95% CI:0.29-0.86, p =0.013). Notably, LDA
significantly lowered the risk of spontaneous preterm birth, not for
iatrogenic. However, the protective role of LDA on SGA was not strong
(23.40% vs. 31.49%, OR:0.74, 95% CI: 0.55-1.00,p =0.063), even calculated in selective SGA (sSGA) subgroups
(20.00% vs. 27.80%, OR:0.72, 95% CI: 0.51-1.01,p =0.060). Considering the coagulation function might be impaired
by aspirin administration, bleeding volume during delivery was recorded,
which was 505.66±300.96 ml and 524.57±445.61 ml in the LDA group and
Control group, respectively (p =0.590). Furthermore, the
incidences of cesarean postpartum hemorrhage in the LDA group and
control group were 3.40% and 3.84% respectively (OR:0.89, 95% CI:
0.35-2.26, p =1.000). (Table 3).