PK parameters Unit Dose Dose Dose P values
2.0 g (n=10) 4.0 g (n=10) 8.0 g (n=10)
Cmax μg /mL 111.28 (18.99) 230.76 (29.16) 352.67 (42.94) <0.001
AUC0-t μg·h /mL 267.09 (59.66) 524.50 (72.87) 822.68 (95.21) <0.001
AUC0-∞ μg·h /mL 274.72 (61.65) 536.06 (78.13) 832.07 (96.91) <0.001
T1/2 h 5.15 (1.74) 5.21 (1.62) 4.28 (1.23) 0.335
Tmax h 0.5 0.5 0.5
Vz L 54.40 (16.97) 56.92 (19.17) 60.00 (19.67) 0.799
Cmax/dose (μg/mL)/g 55.64 (9.50) 57.69 (7.29) 44.08 (5.37) 0.001
AUC0-t/dose (μg·h /mL)/g 133.54 (29.83) 131.12 (18.22) 102.84 (11.90) 0.005
AUC0-∞t/dose (μg·h /mL)/g 137.36 (30.82) 134.01 (19.53) 104.01 (12.11) 0.004