PK parameters Unit Mean (SD) Mean (SD) P Value
1st day 7th day
Cmax (Css-max) μg/mL 181.28 (24.19) 186.32 (28.21) 0.368
AUC0-t (AUCss) μg·h /mL 551.57 (86.35) 577.58 (91.07) 0.091
AUC0-∞ μg·h /mL 562.71 (86.95) 600.71 (99.84) 0.054
T1/2 h 4.69 (1.92) 6.04 (1.87) 0.050
Vz L 49.28 (21.22) 58.28 (17.25) 0.105
Tmax (Tss-max) h 0.5 0.5
DF 7.70 (1.24)
Rac* 1.05 (0.08)