PK parameters |
Unit |
Dose |
Dose |
Dose |
P values |
|
|
2.0 g (n=10) |
4.0 g (n=10) |
8.0 g (n=10) |
|
Cmax
|
μg /mL |
111.28 (18.99) |
230.76 (29.16) |
352.67 (42.94) |
<0.001 |
AUC0-t
|
μg·h /mL |
267.09 (59.66) |
524.50 (72.87) |
822.68 (95.21) |
<0.001 |
AUC0-∞
|
μg·h /mL |
274.72 (61.65) |
536.06 (78.13) |
832.07 (96.91) |
<0.001 |
T1/2
|
h |
5.15 (1.74) |
5.21 (1.62) |
4.28 (1.23) |
0.335 |
Tmax
|
h |
0.5 |
0.5 |
0.5 |
- |
Vz
|
L |
54.40 (16.97) |
56.92 (19.17) |
60.00 (19.67) |
0.799 |
Cmax/dose |
(μg/mL)/g |
55.64 (9.50) |
57.69 (7.29) |
44.08 (5.37) |
0.001 |
AUC0-t/dose |
(μg·h /mL)/g |
133.54 (29.83) |
131.12
(18.22) |
102.84 (11.90) |
0.005 |
AUC0-∞t/dose |
(μg·h /mL)/g |
137.36 (30.82) |
134.01
(19.53) |
104.01 (12.11) |
0.004 |