WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
- ORT has been widely used around the world for many years with
significant curative effect and tolerable adverse effects. It was
clinically used for the management of memory and intellectual
impairment caused by mild to moderate vascular dementia, senile
dementia, and brain trauma.
- Pre-clinical studies have shown that S-ORT is the main active
ingredient in the ORT that can exert substantial pharmacological
effects. In addition, the potential toxic and side effects can be
reduced by decreasing the dosage when it has been used alone, which
can also improve its efficacy, and thereby provide a more accurate
information related to the toxicology/toxicokinetics and
pharmacokinetic/pharmacodynamic relationship.
- All ORT used clinically are in the racemates form currently, and S-ORT
for injection has not been listed and used around the world.