PK parameters |
Unit |
Mean (SD) |
Mean (SD) |
P Value |
|
|
1st day |
7th day |
|
Cmax (Css-max) |
μg/mL |
181.28 (24.19) |
186.32 (28.21) |
0.368 |
AUC0-t (AUCss) |
μg·h /mL |
551.57
(86.35) |
577.58 (91.07) |
0.091 |
AUC0-∞
|
μg·h /mL |
562.71 (86.95) |
600.71 (99.84) |
0.054 |
T1/2
|
h |
4.69 (1.92) |
6.04 (1.87) |
0.050 |
Vz
|
L |
49.28 (21.22) |
58.28 (17.25) |
0.105 |
Tmax (Tss-max) |
h |
0.5 |
0.5 |
- |
DF |
|
|
7.70 (1.24) |
|
Rac* |
|
|
1.05 (0.08) |
|