Conclusion
In conclusion, in recent years, pregnancy is not rare in NF1 patient
because normal fertility and ameliorated quality of life, the course of
pregnancy may be complicated, but maternal mortality is rare. Number and
size of neurofibromas frequently increase in pregnancy especially in the
second trimester. NF1 patient can plan pregnancy and deliver safety with
adequate counseling, but medical team should be prepared for possible
maternal and fetal complications. Our patient is unique because NF1 was
associated with HIV infection, she had four pregnancies, no significant
increase in neurofibroma dimensions and no malignant degeneration was
evident during a seven years follow-up. The association between
pregnancy and HIV seropositive in compliant patient with NF1 may have a
good maternal and neonatal outcome, without evident progression of HIV
disease or negative effects on NF1. National or sovranational registries
may be useful to better understand the long-term effects of pregnancies
on NF1 and vice-versa, also in subgroup of patients such as in the case
described.