Conclusion
In conclusion, in recent years, pregnancy is not rare in NF1 patient because normal fertility and ameliorated quality of life, the course of pregnancy may be complicated, but maternal mortality is rare. Number and size of neurofibromas frequently increase in pregnancy especially in the second trimester. NF1 patient can plan pregnancy and deliver safety with adequate counseling, but medical team should be prepared for possible maternal and fetal complications. Our patient is unique because NF1 was associated with HIV infection, she had four pregnancies, no significant increase in neurofibroma dimensions and no malignant degeneration was evident during a seven years follow-up. The association between pregnancy and HIV seropositive in compliant patient with NF1 may have a good maternal and neonatal outcome, without evident progression of HIV disease or negative effects on NF1. National or sovranational registries may be useful to better understand the long-term effects of pregnancies on NF1 and vice-versa, also in subgroup of patients such as in the case described.