Risk factors of EIARD
The following clinical information was collected as potential factors associated with EIARD: age at the start of OIT and at EPT; history of other allergic diseases; average pace of increasing the amount of antigen during OIT (defined as the difference between the full dose and the starting dose, divided by the duration of OIT); and specific IgE (sIgE) titer (milk and casein, or wheat and ω-5 gliadin) before starting OIT and within 1 year before the EPT (after OIT). sIgE levels were detected using ImmunoCAP® (Thermo Fisher Scientific, Uppsala, Sweden). A level of ≤0.34 kUA/L was fixed at 0.34 kUA/L, indicating no sensitization. Levels >100 kUA/L were fixed at 100 kUA/L.