5.Authors’ contributions
Conceived and designed the experiments: Y-LZ, YZ,Y-Q L. Performed the experiments: X-L W,Q-G C, Q-H H. Analyzed the data: Y-LZ, YX. Contributed reagents/materials/analysis tools: J-J W,L-C J. Wrote the paper: YX, Y-LZ. Revised the manuscript critically for important intellectual content: Y-LZ. All authors read and approved the final manuscript.