Conclusion
High-risk PE imposes a high level of morbidity and mortality. Treatment of this entity, requires diverse, aggressive, expeditious, and multidisciplinary approaches that are tailored to
meet patient-specific risks and needs. ECMO is a useful clinical tool, which can be implemented to provide pulmonary and circulatory support for the emergency treatment of patients with circulatory collapse. EKOS Acoustic pulse thrombolysis concomitantly with V-A ECMO is providing definitive and live saving treatment in patient with high-risk PE and cardiogenic shock.