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\begin{document}

\title{Effect of VA -ECMO Vs Impella on Survival~}



\author[1]{Frank Annie}%
\author[1]{Kayce Boggess}%
\author[1]{Aravinda Nanjundappa}%
\affil[1]{Affiliation not available}%


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  \date{May 24, 2024}


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Effect of VA - ECMO Vs Impella on Survival from Jan 1st 2017 -- Aug
3\textsuperscript{rd} 2020

Frank H Annie, PhD\textsuperscript{1}; Kayce Boggess\textsuperscript{1};
Aravinda Nanjundappa, MD\textsuperscript{2};

1. CAMC Health Education and Research Institute

3200 MacCorkle Ave. SE, Charleston, WV 25304.

2. CAMC Vascular Center of Excellence, Charleston Area Medical Center.

3200 MacCorkle Ave SE, Charleston, WV 25304

Study Locations:

Charleston Area Medical Center, 3100 McCorkle Ave SE, Charleston, WV,
25302 and Charleston Area Medical Center Research Institute and Center
for Clinical Sciences Research, 3200 McCorkle Ave SE, Charleston, WV,
25302

Correspondence:

Frank Annie M.A; MPA, PhD

Research Scientist

CAMC Health Education and Research Institute

3200 MacCorkle Ave. SE,

Charleston, WV 25304

Phone 304-388-9921

Fax: 304-388-9921

Email: Frank.H.Annie@camc.org

Total word count: 451

Author Disclosure Block: None

Key words: ECMO, Impella, MI

Running Title: Effect of VA - ECMO Vs Impella on Survival

Total Number of Tables and Figures: Figures 1

Extracorporeal membrane oxygenation~(ECMO) is used as a heart-lung
bypass to oxygenate and pump blood outside the body. VA -- ECMO supports
both heart and lungs. Impella catheter is a pump that is used to
increase blood flow from the inlet area which pulls from the left
ventricle through the aorta of the heart. As both of these devices are
support devices their effectiveness in terms of mortality as a result of
individuals having a myocardial infarction then that required the
implantation of either an ECMO and or Impella or their long term
survival outcome(1-2).

In order to understand long term survival of ECMO vs Impella we queried
the TriNetx database (Research Network) which is a network of 38 health
care organizations with cases from Jan 1\textsuperscript{st} 2017 --
August 3, 2020. We identified VA-ECMO (N=579) and Impella (N=1,377). We
followed the cases until follow-up was lost. In order to compare the
differences we conducted a Prosperity Score Match with a 1:1 (N=
482/482) match with the covariates (Age, Male, Female, Hypertension,
CAD, CHF, Diabetes, CKD, Smoking History, COPD, Stroke History, Liver
Disease History, Cardiogenic Shock, Medications, ACE, ARB Warfarin).
After the match was complete a measure of association and a Kaplan Meir
survival curve was conducted as long with a long-rank test.

The unmatched age at event of MI that required the use of VA -- ECMO was
(56.1\selectlanguage{ngerman}± 13.5), Impella (67.1±11.9) (P = \textless{}0.01), CAD (70.2\% vs
81.3\%) (P= \textless{}0.01) COPD (13.6\% vs 20.4\%) (P = 0.04), ACE
(26.5\% vs 41.4\%) (P= \textless{} 0.01) Cardiogenic Shock (82.9\% vs
54.8\%) (P=\textless{}0.001). The matched cohort had a difference of
mortality of (45.8\% vs 25.1\%) (P = \textless{}0.01). The Kaplan Meir
Survival Curve showed that VA-ECMO had a much lower chance of survival
compared to Impella with a log-rank test of (P=\textless{}0.01) as seen
in and a lower survival probability of (0.49/0.72).

We found that it appears that VA-ECMO cases even after the PSM was
conducted had worse outcome as compared to Impella cases in terms of
mortality. Even controlling for literature driven covariates it appears
that VA-ECMO as a result of MI have worse outcomes compared to Impella.

Figure Legend - ECMO V IMPELLA (Morality)\selectlanguage{english}
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\includegraphics[width=0.70\columnwidth]{figures/image1/image1}

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\textbf{References}

Garan, A. Reshad, Koji Takeda, Michael Salna, John Vandenberge, Darshan
Doshi, Dimitri Karmpaliotis, Ajay J. Kirtane, Hiroo Takayama, and Paul
Kurlansky. ''Prospective comparison of a percutaneous ventricular assist
device and venoarterial extracorporeal membrane oxygenation for patients
with cardiogenic shock following acute myocardial infarction.'' Journal
of the American Heart Association 8, no. 9 (2019): e012171.

Batsides, George, Joe Massaro, Anson Cheung, Edward Soltesz, Danny
Ramzy, and Mark B. Anderson. ''Outcomes of Impella 5.0 in cardiogenic
shock: a systematic review and meta-analysis.'' Innovations 13, no. 4
(2018): 254-260.

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