ABSTRACT
Aims of Study: To compare dynamic thiol/disulfide homeostasis
between patients with with lung tuberculosis and healthy controls.
Methods: Our study included 50 patients with active lung
tuberculosis and 50 healthy controls. Serum thiol/disulfide was measured
with a new automated spectrometric method developed by Erel and
Neselioglu, and results were compared statistically.
Results: We found that native and total thiol levels were
significantly decreased in patients with lung tuberculosis,
disulfide/native thiol and disulfide/total thiol levels were found to be
higher in lung tuberculosis patients when compared with the control
group. However, disulfide levels were higher in the control group than
in the patient group.
Conclusions: Based on the results of this study, it can be said
that oxidative stress is closely associated with lung tuberculosis
pathogenesis. There is a need for new studies that will show the
possible effects of oxidative stress on lung tuberculosis pathogenesis.