ABSTRACT
Aim of Study: Our aim is to compare dynamic thiol/disulphide
homeostasis between patients with acute pulmonary thromboembolism (PTE)
and healthy controls.
Methods: Our study included 45 patients who were diagnosed with
acute PTE and 50 healthy controls. Serum thiol/disulphide was measured.
Results: We found that the native thiol, total thiol, native
thiol/total thiol levels were significantly lower in the patient group
than the control group, while the disulphide, disulphide/natural thiol,
disulphide/total thiol levels were significantly higher.
Conclusion: We have seen that in patients diagnosed with acute
PTE, the oxidant-antioxidant balance shifts towards the oxidative
direction. The disulfide/natural thiol ratio can be considered as an
oxidative stress parameter in acute PTE. We think that the deterioration
in thiol disulfide balance, together with clinical, laboratory and
radiological findings, may have diagnostic value in acute PTE patients.
KEYWORDS: Acute Pulmonary thromboembolism, oxidative stress,
thiol–disulphide homeostasis.