RESULTS
We included 45 patients with acute pulmonary embolism and 50 healthy volunteers in the study. 23 of our patients were non-massive and 22 of them were submassive patients. 25 patients with PTE (55.6%) were female and 20 patients with PTE (44.4%) were male. 26 control group (52%) were female and 24 control group (48%) were male. We showed the distribution of the patient and control groups by gender in table 1. There was no significant difference between the groups in terms of gender (p = 0.73).
The mean age of the patient group diagnosed with acute pulmonary embolism was 56.87 ± 16.30 years, and the mean age of the control group was 52.84 ± 14.23 years. There was no significant difference between the groups in terms of age (p = 0.20)
Serum native thiol, total thiol and disulphide levels and disulphide/natural thiol,
disulphide/total thiol, natural thiol/total thiol ratio measurements in PTE and control group were shown in table 2. Native thiol measurements were 228.65 ± 47.96 in the PTE group and 301.62 ± 58.34 in the control group. There was a statistically significant difference between the groups in terms of native thiol levels, the mean native thiol level (p =0.000) is lower in the PTE group when compared to the control group. When we evaluated the subgroups of our patients, native thiol levels in non-massive and submassive patient groups were significantly lower than the control group (260.12 ± 40.82, p =0.003, 195.75 ± 29.27, p =0.001). Native thiol levels in non-massive patient group was significantly higher than the submassive patient group (p =0.000).
There was a statistically significant difference between the groups in terms of total thiol levels, and PTE group measurements were found to be lower than the control group (271.73 ± 48.33, 329.76 ± 61.65, p =0.000). While there was no significant difference in total thiol levels between the non-massive patient group and the control group (299.95 ± 42.70, p =0.078), the total thiol levels of the sub-massive patient group was significantly lower than the control group (242.23 ± 34.64, p =0.000). Total thiol levels in non-massive patient group was significantly higher than the submassive patient group (p =0.001).
Disulphide level is higher in the PTE group when compared to the control group, and this difference was statistically significant (21.54 ± 5.19, 14.07 ± 4.04, p =0.000). Disulphide levels in non-massive and submassive patient groups were significantly higher than the control group (19.91 ± 4.80, p =0.000, 23.24 ± 5.15, p =0.000). There was no significant difference in disulphide levels between the non-massive and submassive patient group (p =0.055).
The disulphide/native thiol ratio was higher in the PTE group than the control group, and this difference was statistically significant (9.84 ± 3.13, 4.81 ± 1.61, p =0.000). Disulphide/native thiol ratio in non-massive and submassive patient groups were significantly higher than the control group (7.81 ± 2.33, p =0.000, 11.96 ± 2.40, p =0.000). Disulphide/native thiol ratio in non-massive patient group was significantly lower than the submassive patient group (p =0.000).
Disulphide/total thiol ratio was higher in the PTE group than the control group, and this difference was statistically significant (8.11 ± 2.17, 4.35 ± 1.32, p =0.000). Disulphide/total thiol ratio in non-massive and submassive patient groups were significantly higher than the control group (6.69 ± 1.69, p =0.000, 9.59 ± 1.56, p =0.000). Disulphide/total thiol ratio in non-massive patient group was significantly lower than the submassive patient group (p =0.000).
A statistically significant difference was determined between the groups in native thiol/total thiol ratios. The native thiol/total thiol ratio was lower in the PTE group than the control group (83.77 ± 4.35, 91.29 ± 2.64, p =0.000). Native thiol/total thiol ratio in non-massive and submassive patient groups were significantly lower than the control group (86.61 ± 3.38, p =0.000, 80.81 ± 3.11, p =0.000). Native thiol/total thiol ratio in non-massive patient group was significantly higher than the submassive patient group (p =0.000).