RESULTS
We included 45 patients with acute pulmonary embolism and 50 healthy
volunteers in the study. 23 of our patients were non-massive and 22 of
them were submassive patients. 25 patients with PTE (55.6%) were female
and 20 patients with PTE (44.4%) were male. 26 control group (52%)
were female and 24 control group (48%) were male. We showed the
distribution of the patient and control groups by gender in table 1.
There was no significant difference between the groups in terms of
gender (p = 0.73).
The mean age of the patient group diagnosed with acute pulmonary
embolism was 56.87 ± 16.30 years, and the mean age of the control group
was 52.84 ± 14.23 years. There was no significant difference between the
groups in terms of age (p = 0.20)
Serum native thiol, total thiol and disulphide levels and
disulphide/natural thiol,
disulphide/total thiol, natural thiol/total thiol ratio measurements in
PTE and control group were shown in table 2. Native thiol measurements
were 228.65 ± 47.96 in the PTE group and 301.62 ± 58.34 in the control
group. There was a statistically significant difference between the
groups in terms of native thiol levels, the mean native thiol level (p
=0.000) is lower in the PTE group when compared to the control group.
When we evaluated the subgroups of our patients, native thiol levels in
non-massive and submassive patient groups were significantly lower than
the control group (260.12 ± 40.82, p =0.003, 195.75 ± 29.27, p =0.001).
Native thiol levels in non-massive patient group was significantly
higher than the submassive patient group (p =0.000).
There was a statistically significant difference between the groups in
terms of total thiol levels, and PTE group measurements were found to be
lower than the control group (271.73 ± 48.33, 329.76 ± 61.65, p =0.000).
While there was no significant difference in total thiol levels between
the non-massive patient group and the control group (299.95 ± 42.70, p
=0.078), the total thiol levels of the sub-massive patient group was
significantly lower than the control group (242.23 ± 34.64, p =0.000).
Total thiol levels in non-massive patient group was significantly higher
than the submassive patient group (p =0.001).
Disulphide level is higher in the PTE group when compared to the control
group, and this difference was statistically significant (21.54 ± 5.19,
14.07 ± 4.04, p =0.000). Disulphide levels in non-massive and submassive
patient groups were significantly higher than the control group (19.91 ±
4.80, p =0.000, 23.24 ± 5.15, p =0.000). There was no significant
difference in disulphide levels between the non-massive and submassive
patient group (p =0.055).
The disulphide/native thiol ratio was higher in the PTE group than the
control group, and this difference was statistically significant (9.84 ±
3.13, 4.81 ± 1.61, p =0.000). Disulphide/native thiol ratio in
non-massive and submassive patient groups were significantly higher than
the control group (7.81 ± 2.33, p =0.000, 11.96 ± 2.40, p =0.000).
Disulphide/native thiol ratio in non-massive patient group was
significantly lower than the submassive patient group (p =0.000).
Disulphide/total thiol ratio was higher in the PTE group than the
control group, and this difference was statistically significant (8.11 ±
2.17, 4.35 ± 1.32, p =0.000). Disulphide/total thiol ratio in
non-massive and submassive patient groups were significantly higher than
the control group (6.69 ± 1.69, p =0.000, 9.59 ± 1.56, p =0.000).
Disulphide/total thiol ratio in non-massive patient group was
significantly lower than the submassive patient group (p =0.000).
A statistically significant difference was determined between the groups
in native thiol/total thiol ratios. The native thiol/total thiol ratio
was lower in the PTE group than the control group (83.77 ± 4.35, 91.29 ±
2.64, p =0.000). Native thiol/total thiol ratio in non-massive and
submassive patient groups were significantly lower than the control
group (86.61 ± 3.38, p =0.000, 80.81 ± 3.11, p =0.000). Native
thiol/total thiol ratio in non-massive patient group was significantly
higher than the submassive patient group (p =0.000).