Asymptomatic peripheral lymphadenopathy Medullary infiltration (lymphoma if the neoplastic medullary infiltrate is <25%, otherwise leukemia) with any secondary alteration of blood count. Localization-dependent symptoms (e.g. abdominal pain, chest pain, dyspnoea …) Systemic symptoms: - evening fever or low-grade fever night sweats weight loss (> 10% in the past 6 months) pruritus sine materia