Interaction analysis between RB and MET protein
Based on data available in BioGRID and STRING databases, no direct interaction between RB1 and MET proteins could be established. This is supported by the different subcellular localizations of the wild-type proteins, as RB1 and MET act in diverse subcellular compartments (in the nucleoplasm and in the cytoplasm, respectively).
However, RB1 and MET share multiple interaction partners. Based on BioGRID database, common interacting partners include CDK4, CDK6, GRB2, MYC, and RAF1 proteins, as well. Thus, simultaneous functional changes of RB1 and MET may basically transactivate the existing signaling networks.