Introduction:
Solid Pseudopapillary tumors of the pancreas (SPTPs) are cystic and solid neoplasms [1]. They are rare pancreatic neoplasms occurring most commonly in females in the second or third decade and account about 0.17–2.7% of all pancreatic tumors [1, 2]. Many studies from 1961 until 2012 report that the most frequent symptom is abdominal pain, but there are no symptoms in the rest of the cases and the diagnosis is made through routine examination [3]. The monomorphic and bland morphology of SPTP cells make it difficult to be differentiated from other pancreatic tumors, especially Neuroendocrine tumors. Immunohistochemistry (IHC) is a crucial factor in making the accurate diagnosis. Here, we present a difficult-to-diagonse (SPTP) case due to the almost subtotal cystic degeneraton and only scanty residual tumor nests in the wall.