Fig. 1 Schematic of method used to identify potential multidrug
interactions (pMDIs) and associated potential adverse drug events
(pADEs). Step 1: each drug-drug pair in the drug-drug interaction table
from NYP was represented as a Set (A ) and numbered consecutively
(Set A 1, Set A 2…)
Step 2: a unique MED-LIST set (Set B ) was generated for each
patient and included all the medications on the patient’s list. TheB sets of each patient’s medications list were numbered
consecutively (Set B 1, SetB 2…). Step 3: For each SetA n in the DRUG-DRUG INTERACTION TABLE, we checked
to see if it was a subset of the patient’s MED-LIST, SetB n. Step 4: Overlapping drug-drug pairs were
identified using network analysis. Step 5: potential ADEs associated
with pMDIs were identified by consulting the NYP drug-drug interaction
table which includes a detailed description of adverse event associated
with a particular drug-drug interaction.