Expression of signatures by gene set variation analysis
Gene set variation analysis (GSVA) was used to calculate sample-wise enrichment scores (ESs) (17) for six asthma-associated gene signatures. These gene sets each relate to a specific aspect of airway inflammation and asthma pathogenesis (Supplementary Table S2 ). The correlations between ESs and expression of ACE2, TMPRSS2, and FURIN were calculated using Spearman’s correlation.