Clinical characteristics
Headache (83%), nausea/vomiting (78%), and visual disturbances (37%)
were the most frequently reported symptoms described by families. All
114 patients had surgery for their disease, 42% (n=48) of the surgeries
occurred at INCA. GTR, as described by the neurosurgeon, was achieved in
65 patients (57%). After MRI imaging 52% (n=59) of the patients showed
less than 1.5 cm2 of residual tumor. Regarding
histology the majority were non-specific medulloblastoma (86%),
followed by desmoplastic/extensive nodularity (4.4%) and classic
histology (5.3%). According to the Chang Classification, 35% (n=40)
were considered to have metastatic disease (M+) at diagnosis.
Fifty-seven percent were defined as HR patients (n=65). One hundred and
five patients received chemotherapy (92%) and 109 patients received
radiation therapy (95%) (Table 2).