n Drugs that triggered PGx-testing Relevant gene(s) Detected phenotype variants1 Patients with SONOGEN XP recommendation to change triggering drug Patients with clinical expert recommendation to change triggering drug Patients with additional clinical expert recommendations for current but non-triggering drug(s)2
102 All patients with specific indication n.a. n.a. 36 (35.3 %) 33 (32.4 %) 23 (22.5 %)
60 Clopidogrel 2C19 1 PM / 19 IM / 19 UM 20 (33.3 %) 19 (31.6 %) 16 (26.7 %)
15 Tamoxifen 2D6 3 IM / 1 UM 3 (20.0 %) 1 (6,7 %) 0
9 Polypsycho-pharmacotherapy 1A2 2D6 2C19 1A2: 6 UM 2D6: 7 IM / 1 PM 2C19: 6 UM 5 (55.6 %) 3 (33.3 %) 3 (33.3 %)
7 Opioids OPRM 2D6 OPRM1 3 decreased function 2D6: 4 IM 4 (57.1 %) 3 (42.9 %) 4 (57.1 %)
6 Statins SLCO1B1 4 decreased function 2 (33.3 %) 4 (66.7 %) 0 (%)
2 Phenprocoumon VKORC1 CYP4F2 CYP2C9 1 VKORC: G/G / 1 VKORC G/A
2 CYP2C9: *1/*1
2 CYP4F2: C/C 1 (50.0 %) 2 (100 %) 0
2 Chemotherapy DPYD 0 0 0 0
1 PPI 2C19 1 UM 1 (100 %) 1 (100 %) 0
33 Screening n.a. n.a. n.a. n.a. 3 (9.1 %)