7 References
Aizawa H, Saito Y, Nakamura T, Inoue M, Imanari T, Ohyama Y, et al. (1998). Downregulation of the Klotho gene in the kidney under sustained circulatory stress in rats. Biochemical and biophysical research communications 249: 865-871.
Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, et al. (2012). Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol 13: 155.
Allan SM, & Rothwell NJ (2001). Cytokines and acute neurodegeneration. Nature reviews Neuroscience 2: 734-744.
Bloch L, Sineshchekova O, Reichenbach D, Reiss K, Saftig P, Kuro-o M, et al. (2009). Klotho is a substrate for alpha-, beta- and gamma-secretase. FEBS letters 583: 3221-3224.
Chen CD, Podvin S, Gillespie E, Leeman SE, & Abraham CR (2007). Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17. Proceedings of the National Academy of Sciences of the United States of America 104: 19796-19801.
Clinton SM, Glover ME, Maltare A, Laszczyk AM, Mehi SJ, Simmons RK, et al. (2013). Expression of klotho mRNA and protein in rat brain parenchyma from early postnatal development into adulthood. Brain research 1527: 1-14.
D’Angelo B, Astarita C, Boffo S, Massaro-Giordano M, Antonella Ianuzzi C, Caporaso A, et al. (2017). LPS-induced inflammatory response triggers cell cycle reactivation in murine neuronal cells through retinoblastoma proteins induction. Cell Cycle 16: 2330-2336.
Dai D, Yuan J, Wang Y, Xu J, Mao C, & Xiao Y (2019). Peli1 controls the survival of dopaminergic neurons through modulating microglia-mediated neuroinflammation. Scientific reports 9: 8034.
Duce JA, Podvin S, Hollander W, Kipling D, Rosene DL, & Abraham CR (2008). Gene profile analysis implicates Klotho as an important contributor to aging changes in brain white matter of the rhesus monkey. Glia 56: 106-117.
Erben RG (2016). Update on FGF23 and Klotho signaling. Mol Cell Endocrinol 432: 56-65.
Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. (2000). Inflamm-aging. An evolutionary perspective on immunosenescence. Annals of the New York Academy of Sciences 908: 244-254.
German DC, Khobahy I, Pastor J, Kuro OM, & Liu X (2012). Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiol Aging 33: 1483 e1425-1430.
Ghosh S, May MJ, & Kopp EB (1998). NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annual review of immunology 16: 225-260.
Glezer I, Munhoz CD, Kawamoto EM, Marcourakis T, Avellar MC, & Scavone C (2003). MK-801 and 7-Ni attenuate the activation of brain NF-kappa B induced by LPS. Neuropharmacology 45: 1120-1129.
Guadagno J, Xu X, Karajgikar M, Brown A, & Cregan SP (2013). Microglia-derived TNFα induces apoptosis in neural precursor cells via transcriptional activation of the Bcl-2 family member Puma. Cell death & disease 4: e538.
Guo Y, Zhuang X, Huang Z, Zou J, Yang D, Hu X, et al. (2018). Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-κB-mediated inflammation both in vitro and in vivo. Biochimica et biophysica acta Molecular basis of disease 1864: 238-251.
Heneka MT, Kummer MP, & Latz E (2014). Innate immune activation in neurodegenerative disease. Nature reviews Immunology 14:463-477.
Hui H, Zhai Y, Ao L, Cleveland JC, Jr., Liu H, Fullerton DA, et al. (2017). Klotho suppresses the inflammatory responses and ameliorates cardiac dysfunction in aging endotoxemic mice. Oncotarget 8: 15663-15676.
Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, et al. (2004). Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS letters 565: 143-147.
Kawamoto EM, Lepsch LB, Boaventura MF, Munhoz CD, Lima LS, Yshii LM, et al. (2008). Amyloid beta-peptide activates nuclear factor-kappaB through an N-methyl-D-aspartate signaling pathway in cultured cerebellar cells. Journal of neuroscience research 86:845-860.
Kempuraj D, Thangavel R, Natteru PA, Selvakumar GP, Saeed D, Zahoor H, et al. (2016). Neuroinflammation Induces Neurodegeneration. Journal of neurology, neurosurgery and spine 1.
Kim JJ, & Diamond DM (2002). The stressed hippocampus, synaptic plasticity and lost memories. Nature reviews Neuroscience 3:453-462.
King GD, Rosene DL, & Abraham CR (2012). Promoter methylation and age-related downregulation of Klotho in rhesus monkey. Age (Dordrecht, Netherlands) 34: 1405-1419.
Kinoshita PF, Yshii LM, Orellana AMM, Paixão AG, Vasconcelos AR, Lima LdS, et al. (2017). Alpha 2 Na+,K+-ATPase silencing induces loss of inflammatory response and ouabain protection in glial cells. Scientific reports 7: 4894.
Kotas ME, & Medzhitov R (2015). Homeostasis, inflammation, and disease susceptibility. Cell 160: 816-827.
Krick S, Baumlin N, Aller SP, Aguiar C, Grabner A, Sailland J, et al. (2017). Klotho Inhibits Interleukin-8 Secretion from Cystic Fibrosis Airway Epithelia. Scientific reports 7: 14388.
Kuro-o M (2019). The Klotho proteins in health and disease. Nature Reviews Nephrology 15: 27-44.
Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. (1997). Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390: 45-51.
Kwon HS, & Koh S-H (2020). Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes. Translational Neurodegeneration 9: 42.
Li L, Wang Y, Gao W, Yuan C, Zhang S, Zhou H, et al. (2015). Klotho Reduction in Alveolar Macrophages Contributes to Cigarette Smoke Extract-induced Inflammation in Chronic Obstructive Pulmonary Disease. The Journal of biological chemistry 290: 27890-27900.
Li SA, Watanabe M, Yamada H, Nagai A, Kinuta M, & Takei K (2004). Immunohistochemical localization of Klotho protein in brain, kidney, and reproductive organs of mice. Cell Struct Funct 29: 91-99.
Liu X, Wu Z, Hayashi Y, & Nakanishi H (2012). Age-dependent neuroinflammatory responses and deficits in long-term potentiation in the hippocampus during systemic inflammation. Neuroscience 216:133-142.
Maekawa Y, Ishikawa K, Yasuda O, Oguro R, Hanasaki H, Kida I, et al. (2009). Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation. Endocrine 35: 341-346.
Mazucanti CH, Kawamoto EM, Mattson MP, Scavone C, & Camandola S (2019). Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 39: 1544-1556.
Medzhitov R (2008). Origin and physiological roles of inflammation. Nature 454: 428-435.
Nabeshima Y (2002). Klotho: a fundamental regulator of aging. Ageing Res Rev 1: 627-638.
Nazem A, Sankowski R, Bacher M, & Al-Abed Y (2015). Rodent models of neuroinflammation for Alzheimer’s disease. Journal of neuroinflammation 12: 74.
Ohyama Y, Kurabayashi M, Masuda H, Nakamura T, Aihara Y, Kaname T, et al. (1998). Molecular cloning of rat klotho cDNA: markedly decreased expression of klotho by acute inflammatory stress. Biochemical and biophysical research communications 251: 920-925.
Ownby RL (2010). Neuroinflammation and cognitive aging. Current psychiatry reports 12: 39-45.
Razzaque MS (2009). The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis. Nat Rev Endocrinol 5: 611-619.
Rivest S (2009). Regulation of innate immune responses in the brain. Nature reviews Immunology 9: 429-439.
Sun L, Shen R, Agnihotri SK, Chen Y, Huang Z, & Büeler H (2018). Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death. Scientific reports 8: 383.
Thomson LM, & Sutherland RJ (2005). Systemic administration of lipopolysaccharide and interleukin-1beta have different effects on memory consolidation. Brain research bulletin 67: 24-29.
Wang C, Liu Z, Ke Y, & Wang F (2019). Intrinsic FGFR2 and Ectopic FGFR1 Signaling in the Prostate and Prostate Cancer. Frontiers in Genetics 10.
Wang Y, & Sun Z (2009). Current understanding of klotho. Ageing research reviews 8: 43-51.
Xiao NM, Zhang YM, Zheng Q, & Gu J (2004). Klotho is a serum factor related to human aging. Chinese medical journal 117: 742-747.
Yshii LM, Denadai-Souza A, Vasconcelos AR, Avellar MC, & Scavone C (2015). Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells. Journal of neuroinflammation 12: 193.
Zeldich E, Chen CD, Boden E, Howat B, Nasse JS, Zeldich D, et al.(2019). Klotho Is Neuroprotective in the Superoxide Dismutase (SOD1(G93A)) Mouse Model of ALS. Journal of molecular neuroscience : MN 69: 264-285.
Zhao Y, Banerjee S, Dey N, LeJeune WS, Sarkar PS, Brobey R, et al. (2011). Klotho depletion contributes to increased inflammation in kidney of the db/db mouse model of diabetes via RelA (serine)536 phosphorylation. Diabetes 60: 1907-1916.
Zhou HJ, Li H, Shi MQ, Mao XN, Liu DL, Chang YR, et al. (2017). Protective Effect of Klotho against Ischemic Brain Injury Is Associated with Inhibition of RIG-I/NF-κB Signaling. Frontiers in pharmacology 8: 950.