5 Discussion
In conclusion, our work
demonstrated for the first time in primary cortical neuronal culture an
anti-inflammatory and neuroprotective effect of the α-Klotho protein as
the citotoxiciyty of GCM could be rescued by α-Klotho pretreatment
(GCM-KL). This neuroprotective α-Klotho effect is at least partially
mediated by astrocyte NF-κB modulation of neuroinflammation. These data
suggest that α-Klotho can act not just in the metabolic coupling between
neurons and astrocytes (Mazucanti, Kawamoto et al., 2019), but it is
also an important player in modulating neuroinflammation which is
important to integrate insulin and glutamate action in neurons. Thus,
α-Klotho’s therapeutic potential is evidenced in pathological processes
that have a neuroinflammatory component.