Distribution of the developed models on current VUS
Finally, we ran our models on a set of ClinVar variants currently classified as VUS (Figure 4). The Random Forest model predicts that approximately three quarters of the variants to be pathogenic and one quarter benign. On the distribution of probability of pathogenicity, there is a sharp peak in values of probability of pathogenicity close to 1, and a less marked peak in values around thirty percent. The support vector machine model predicts that approximately two thirds of the variants to be pathogenic and one third benign. On the distribution of probability of pathogenicity, there is a sharp peak in values of probability of pathogenicity close to 1, and a less marked peak in values close to zero. The multilayer perceptron model predicts approximately three quarters of the variants to be pathogenic and one quarter benign. Its distribution of probability behaves in a similar fashion to the SVM model.