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\begin{document}

\title{Prognostic Value of Preoperative Inflammation Markers in Non-Muscle
Invas\selectlanguage{polish}ı\selectlanguage{english}ve Bladder Cancer\selectlanguage{english}}



\author[1]{Hüseyin Alperen Yıldız}%
\author[2]{Dogan Deger}%
\author[3]{Guven Aslan}%
\affil[1]{Malazgirt State Hospital}%
\affil[2]{Edirne State Hospital}%
\affil[3]{Dokuz Eylül University}%


\vspace{-1em}



  
  \date{June 13, 2024}


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\selectlanguage{english}
\begin{abstract}
Purpose: To investigate the prediction values of the preoperative NLR,
LMR, PLR, MPV, RDW for recurrence and progression of patients with
non-muscle invasive bladder cancer (NMIBC). Methods: In this prospective
study, 94 consecutive patients, newly diagnosed with NMIBC between July
2017 - August 2018 were included. The blood samples were collected from
patients before transurethral resection of bladder tumor (TURB) and NLR,
LMR, PLR, RDW, MPV values were calculated. The effect of these
preoperative inflammatory parameters and other clinicopathological
parameters on recurrence and progression rates were evaluated.
Kaplan-Meier and multivariate Cox regression analyses were performed to
identify significant prognostic variables. Results: The mean follow-up
was 11 \selectlanguage{ngerman}± 6.4 months. Recurrence was observed in 35.1\% and progression
was detected in 7.4\% of the patients. Neutrophil-lymphocyte ratio was
statistically significantly associated with both recurrence (p = 0.01)
and progression (p = 0.035) whereas lymphocyte-monocyte ratio was only
associated with recurrence (p = 0.038). In the survival analyses, the
relationship between recurrence and LMR was confirmed in both univariate
(p = 0.021) and multivariate (p = 0.022) analyses. The relationship
between NLR and recurrence was confirmed in univariate analysis (p =
0.019), however in multivariate analysis was found to be statistically
insignificant (p = 0.051). Conclusions: Lymphocyte-monocyte ratio might
be an easy obtainable, non-invasive and cost-effective method for
predicting recurrence of disease in patients with non-muscle invasive
bladder cancer.%
\end{abstract}\selectlanguage{ngerman}%



\sloppy


Prognostic Value of Preoperative Inflammation Markers in Non-Muscle
Invas\selectlanguage{polish}ı\selectlanguage{english}ve Bladder Cancer

H\selectlanguage{ngerman}üseyin Alperen Y\selectlanguage{polish}ı\selectlanguage{english}ld\selectlanguage{polish}ı\selectlanguage{english}z \textsuperscript{a,*}, M\selectlanguage{ngerman}üslim Do\selectlanguage{polish}ğ\selectlanguage{english}an
De\selectlanguage{polish}ğ\selectlanguage{english}er\textsuperscript{b}, G\selectlanguage{ngerman}üven Aslan \textsuperscript{c}

\textsuperscript{a} Department of Urology, Malazgirt State Hospital,
Mu\selectlanguage{polish}ş, \selectlanguage{english}Turkey

\textsuperscript{b} Department of Urology, Edirne State Hospital,
Edirne, Turkey

\textsuperscript{c} Department of Urology, Dokuz Eyl\selectlanguage{ngerman}ül University,
School of Medicine, \selectlanguage{polish}İ\selectlanguage{english}zmir, Turkey

Short Title: Inflammation markers as a predictive tool in NMIBC

*Corresponding Author: H\selectlanguage{ngerman}üseyin Alperen Y\selectlanguage{polish}ı\selectlanguage{english}ld\selectlanguage{polish}ı\selectlanguage{english}z

Malazgirt State Hospital, Department of Urology

Address: Saltukgazi Mahallesi, Hastane Cd., Malazgirt, Mu\selectlanguage{polish}ş, \selectlanguage{english}Turkey,
49400

Tel: +902324443511

E-mail: h.alperenyildiz@gmail.com

Acknowledgments:

None

Disclosure Statement:

The authors have no conflicts of interest to declare.

Funding Sources:

The authors received~no~specific~funding~for this work.\selectlanguage{english}
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