INTRODUCTION
Cytomegalovirus (CMV) is a DNA virus belonging to herpesvirus. It
modulates host immunity, and may cause immune dysfunction leading to
immunosuppression and auto-immune phenomenon. 1 CMV
can affect the functioning of both innate and adaptive immune responses
by the destruction of crucial immune substrate, alteration of
transcriptional and translational control, alteration of signal
transduction cascades, and the production of novel interfering proteins.2 CMV can infect endothelial cells in vitro with
certain strains leading to complete lysis of the endothelial cells.3 Infection with CMV can modulate the activity of the
endothelium-from anticoagulant to pro-coagulant state.4,5 It can also induce platelet adherence and
aggregation in infected endothelium, with acute-phase infections
associated with thrombosis. 6 CMV infection is
associated with the development of atherosclerosis in the coronary
arteries. 7 We discuss a unique case of a young
immunocompetent patient with low cardiovascular risk, presenting with
acute myocardial infarction, with evidence of acute CMV infection.