INTRODUCTION
Cytomegalovirus (CMV) is a DNA virus belonging to herpesvirus. It modulates host immunity, and may cause immune dysfunction leading to immunosuppression and auto-immune phenomenon. 1 CMV can affect the functioning of both innate and adaptive immune responses by the destruction of crucial immune substrate, alteration of transcriptional and translational control, alteration of signal transduction cascades, and the production of novel interfering proteins.2 CMV can infect endothelial cells in vitro with certain strains leading to complete lysis of the endothelial cells.3 Infection with CMV can modulate the activity of the endothelium-from anticoagulant to pro-coagulant state.4,5 It can also induce platelet adherence and aggregation in infected endothelium, with acute-phase infections associated with thrombosis. 6 CMV infection is associated with the development of atherosclerosis in the coronary arteries. 7 We discuss a unique case of a young immunocompetent patient with low cardiovascular risk, presenting with acute myocardial infarction, with evidence of acute CMV infection.