Methods
VIP-HL automates 13 out of 24 ACMG/AMP rules specified by ClinGen HL-EP,
namely PVS1, PS1, PM1, PM2, PM4, PM5, PP3, BA1, BS1, BS2, BP3, BP4, and
BP7 (Oza et al. 2018). The development and optimization of VIP-HL are
described in three sections: (1) rule selection, optimization and
implementation; (2) Benchmarking and comparative analysis; (3) web
interface development.