The practical significance of this study is based on the confirmed link between the reduced expression of the CBR1, CBR1a, and CBR2 and the increased likelihood of PTB. These findings indicate that the receptors might serve as biomarkers for predicting PTB. CBRs could be included in prenatal screening programmes to identify pregnancies at an elevated risk of PTB and allow for the early adoption of preventative interventions. Furthermore, gaining a deeper understanding of the function of CBRs in PTB could potentially lead to the creation of innovative therapeutic strategies, potentially using CBR expression modulation to delay or prevent PTB. However, further research is needed to confirm the practical application of these findings.