Cannabinoid receptors (CBRs) are involved in both the male and female reproductive systems (the oviduct, uterus, embryo) [22,23]. The ECS plays a significant role in the regulation of oogenesis, embryo development, embryo transport, implantation, and placental development, as well as pregnancy and childbirth [24,25]. ECS dysregulation might contribute to delayed embryonic development, poor blastocyst implantation, inhibited decidualization, compromised placentation, pre-eclampsia, ectopic pregnancy and miscarriage [22,24,26]. While many studies showed that the ECS affected pregnancy outcomes, the precise role of the CBR is yet to be fully understood.