Introduction
Cryptococcosis is one of the common mycological condition leading to morbidity and mortality in patients with AIDS.1Cryptococcus can cause life threatening infections like meningoencephalitis and disseminated cryptococcosis in immunocompromised patients.2 According to the studies, 10 to 25% of AIDS patients with cryptococcosis die even if they have received antifungal therapy and 30 to 60% die within the first year of onset of the infection.1
We present a case of disseminated cryptococcosis in a patient with HIV, which were both diagnosed by clinical autopsy using Minimally Invasive Tissue Sampling (MITS) technique.3 In Nepal, clinical autopsies are not usually conducted and forensic autopsies are not routinely backed up with histopathological, microbiological and other ancillary tests. In this case, we performed MITS procedure along with histopathological, serological and microbiological tests as a part of a research project – Determining Efficiently the Cause of Death among Adults and Generating Mortality Evidence at MITS Alliance Unit Nepal (DECODE MAUN Nepal).