Statistical analysis
All statistical analyses were performed using SPSS version 25.0 (IBM Corp., Armonk, NY, USA). The Pearson’s chi-square test and independentt -test were used to compare the frequency and mean of categorical and continuous valuables, respectively, between children in current AR and control groups. Multivariate logistic regression analysis was used to calculate adjusted OR (aORs) and 95% confidence interval (CI) after adjusting for age, gender, body mass index (BMI) of children, exposure to tobacco smoke during early life, parental history of allergic disease, maternal education, parental income, and area of residence.
The ERS and PRS were divided into two groups, low and high, by median value, and the low group was used as a reference. Multiplicative interaction between ERS and PRS on current AR in children was calculated in the multivariate logistic regression model.