Methods
We conducted a cross-sectional study, comprising 1,797 children aged
9–12 years. Weighted
environmental risk score (ERS)
was calculated by using four hygienic environmental factors, including
antibiotic use during infancy, cesarean section delivery, breast milk
feeding, and having older siblings. Weighted
polygenic risk score (PRS) was
calculated by using four single nucleotide polymorphisms (SNPs),
including interleukin-13 (rs20541), cluster of differentiation 14
(rs2569190), toll-like receptor 4 (rs1927911), and glutathione
S-transferase P1 (rs1695). Multivariable logistic regression analysis
was used.