Figure 2 . Graphical summary of the cellular location and biological process categorization for genes involved in the inflammasome activation pathway found to be missing across all bats. A) Gene loss ofspecific epithelial α and β defensins. B) Gene losses of NKG2D ligands RAET1 and H60, involved in recruiting NK cells and IFN-γ stimulation. C) Loss of the PYRIN and HIN domain (PYHIN) gene family (AIM2, IFI16, PYHIN1), along with the IFN-γ inducible related GTPase genes (IRGM1, IRGM2, IGTO, IIGP, TGTP2); loss of IRGM1 and 2 results in increase macrophage survival and CD4+ T cells apoptosis.