a Localized PCa defined as stage T1 or T2; Advanced PCa defined as stage T3 or T4 and or distant metastases;b Adjusting for the same variables in Table 2; c Medians of 42.83 ng/mg creatinine for melatonin, 23.92 ng/mg creatinine for cortisol, and 1.81 for MT/C ratio. * c Melatonin/Cortisol ratio; **Prostate-specific antigen (ng/dL).