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We found a statistically significant correlation between lower M/C ratio or levels of first spot urinary melatonin-sulfate and the risk of prostate cancer. Furthermore, we reached the conclusion that patients with both low PSA levels and M/C ratios beyond 10 ng/mL were much more exposed to advanced (end-stage) disease and prostate cancer.
Conflict of Interest: There is no conflict of interest in the present study.
Financial Disclosure: No financial support or funds were used for the study.
Acknowledgements: none declared