Limitations:
This single-centre study has several limitations. It was performed with limited sample size and short FU duration. Echocardiographic analyses were not performed or validated by an independent core lab. Invasive assessment of the left atrial pressure or exercise echocardiography was not done. Further evaluation of the impact of MG on outcomes according to the aetiology of MR (FMR vs DMR) was not possible owing to the too low number of patients with elevated MG. To validate the predictive value of parameters for adverse outcomes and unfavourable MG appropriately powered multicentric studies with a larger patient cohort, a longer FU and subgroup and multivariate analysis according to cut-off values and/or propensity matching, are required.