3.3.4 | Need for mechanical
ventilation during hospitalization
In this meta-analysis, the random effect model (REM) was applied, as
significant heterogeneity was observed in the fixed-effect model (FEM)
(I2 = 72%). Meta-analysis estimated that the MISA
group had a lesser need for mechanical ventilation during
hospitalization (RR : 0.64, 95% CI : 0.49 to 0.82, p = .0005, 8 studies14-17,19,21-23 (n = 1350)). The heterogeneity did not
change significantly after removing each trial one by one. The exclusion
of two studies 14,19 yielded similar results and
failed to significantly reduce the heterogeneity (RR : 0.66, 95% CI :
0.48 to 0.91, I2 = 51%, p = .01, 6 studies15-17,21-23 (n = 919)) (Figure 2D).