3.2 |
Risk of bias assessment for all included studies
All included studies were generally considered to be low or moderate
risk according to the Cochrane assessment standards for RCT. Among them,
11 trials 14,16,18-26 reported the method of random
sequence generation, and 11 trials 14,16,19-26described the specific allocation concealment methods. Due to the
particularity of the intervention, blinding was not possible in all
trials, and blinding of researchers and subjects was assessed as high
risk. However, almost all studies described the criteria for surfactant
delivery 14-26 and rescue intubation14,16-26, so as to minimize such bias. Twelve articles14,16-26 reported complete outcome data. For reporting
bias, five studies 15,17,18,22,23,26 showed unclear
bias because they were not registered in a public trial registry, and
three studies 20,24,25 showed high risk (Table 2).