Introduction
Hemophilia A is an X-linked congenital deficiency of coagulation factor
VIII and is characterized by spontaneous or prolonged bleeding after
trauma. Individuals with the most severe form, hemophilia A, typically
develop symptoms during infancy and get diagnosed by a demonstration of
serum coagulation factor VIII levels that are <1% of the
normal. These individuals require lifelong plasma-derived or recombinant
coagulation factor concentrate routinely or prior to surgical procedures
to prevent bleeding and are usually excluded from contact sports or
other activities or professions with a high risk of trauma and resultant
bleeding. It is very unusual for the severe form of hemophilia A to
present in an adult, who reports no prior abnormal bleeding symptoms.