Search strategy
Online databases including PubMed, Cochrane Library, Web of Science,
Embase, and Google Scholar were searched from inception to January 2021
to identify relevant studies. In addition, supplementary searches were
conducted through the WHO International Clinical Trials Registry
Platform (ICTRP) search portal and grey literature. The main search
strategies were as follows: (smok* OR cigarette OR tobacco OR nicotine)
AND
(Alcohol*
OR drink) AND (cessation OR quit* OR abstinence OR stop*) AND (drug OR
medicine OR pharmaco*) AND (“random*” OR “blind*” OR
“single-blind*” OR “double-blind*” OR “treble-blind*” OR
“triple-blind*”).
Inclusion
and exclusion criteria
Only randomized controlled trials (RCTs) were included. The inclusion
criteria were as follows: 1) Population:
smokers
with alcohol dependence; 2) Intervention: the experimental group
accepted pharmacotherapies and the control group received a placebo; 3)
Outcomes: only the indicators related to smoking were included, such as
smoking cessation rate and changes in the number of cigarettes per day.
Studies that were duplicate reports or with insufficient data, such as
protocols, conference proceedings, or abstracts, were excluded. Studies
written in languages other than English were not included.