NO Synthase but not NO, HNO or
H2O2 Mediates Endothelium-Dependent
Relaxation of Resistance Arteries from Patients with Resistant
Cardiovascular Disease.
Running title: Endothelium in patients’ resistance arteries
Maximilian Matthies1, Kristoffer
Rosenstand1, Inger Nissen1, Stan
Muitjens1, Lars P. Riber2, Jo G. R.
De Mey1,3,*, Maria Bloksgaard1.
1Department of Molecular Medicine, University of
Southern Denmark, Odense, Denmark; 2Department of
Cardiac, Thoracic and Vascular Surgery, Odense University Hospital;3Department of Pharmacology and Personalized Medicine,
Maastricht University, Maastricht, the Netherlands.
Word count (excluding Methods, Figure Legends, and References):
4499
Author Contributions: M.B. and J.G.R. DM designed the study.
M.M., K.R., I.N. S.M. performed the experiments. L.P.R. kindly provided
the access to the human tissue biopsies. M.M., J.G.R. DM and M.B.
interpreted the data and wrote the manuscript. J.G.R. DM and M.B.
critically reviewed the manuscript. All authors approved the final
version of the manuscript.
Conflict of interest statement: The authors declare no
conflicts of interest.
*corresponding author
Jo G. R. De Mey, Ph.D.
University of Southern Denmark
Department of Molecular Medicine, Cardiovascular and Renal Research Unit
J.B.Winsløws Vej 21,3rd floor
DK-5000 Odense C
jdemey@health.sdu.dk
+4565503757