Effects of inhibition of prostanoid, oxidative and nitrosative processes on the sensitivity to the contractile effect of ET-1 in pericardial resistance arteries. Individual data points show the concentration of ET-1 that was needed to cause a contraction of similar amplitude than that induced by 32 mM K⁺. A , in the absence and presence of 100 µM L-NAME, 300 µM c-PTIO and 10 µM ODQ during incubation without or with 10 µM indomethacin (INDO). B , effects of 3 mM NAC, 3 mM DETCA and 50 mM amitrole; C , 2000 U/ml CAT, 2000 U/ml CAT + 100 µM L-NAME and 100 µM L-NAME; andD , 100 µM 7-NI, 3 µM NPLA and 100 µM L-NAME. Data are also shown as median and IQR; N = 6-15. * , P < 0.05 significantly different from control; #, P < 0.05 compared to Control + INDO. Statistical significance of differences was assessed by one-way mixed-effects ANOVA corrected for multiple comparisons by Dunett’s post-hoc test.