NO Synthase but not NO, HNO or H2O2 Mediates Endothelium-Dependent Relaxation of Resistance Arteries from Patients with Resistant Cardiovascular Disease.
Running title: Endothelium in patients’ resistance arteries
Maximilian Matthies1, Kristoffer Rosenstand1, Inger Nissen1, Stan Muitjens1, Lars P. Riber2, Jo G. R. De Mey1,3,*, Maria Bloksgaard1.
1Department of Molecular Medicine, University of Southern Denmark, Odense, Denmark; 2Department of Cardiac, Thoracic and Vascular Surgery, Odense University Hospital;3Department of Pharmacology and Personalized Medicine, Maastricht University, Maastricht, the Netherlands.
Word count (excluding Methods, Figure Legends, and References): 4499
Author Contributions: M.B. and J.G.R. DM designed the study. M.M., K.R., I.N. S.M. performed the experiments. L.P.R. kindly provided the access to the human tissue biopsies. M.M., J.G.R. DM and M.B. interpreted the data and wrote the manuscript. J.G.R. DM and M.B. critically reviewed the manuscript. All authors approved the final version of the manuscript.
Conflict of interest statement: The authors declare no conflicts of interest.
*corresponding author
Jo G. R. De Mey, Ph.D.
University of Southern Denmark
Department of Molecular Medicine, Cardiovascular and Renal Research Unit
J.B.Winsløws Vej 21,3rd floor
DK-5000 Odense C
jdemey@health.sdu.dk
+4565503757