Methods
A protocol paper detailing the methods for this systemic review and
meta-analysis have been previously published(9). Our systematic review
protocol was submitted to the International Prospective Register of
Systematic Reviews (PROSPERO) on the 20th of April 2020 and accepted on
the 6th July 2020 (registration number
CRD42020177386). We have presented the data using the Preferred
Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)
statement(10), the Meta-Analyses of Observational Studies checklist
(MOOSE)(11) and the Cochrane Handbook for Systematic Reviews of
Interventions(12). Information regarding registration can be accessed
from http://www.crd.york.ac.uk/PROSPERO.
Eligibility Criteria:
Eligibility of studies included in this systematic review was based on
pre-planned inclusion and exclusion criteria applied to each of the
following domains: participant, exposure, comparator, study type and
outcome.