Results:
Greater AF burden (p=0.003) and longer AF episodes (p=0.013) were associated with impaired QoL (Vitality score only) in simple linear regression analyses. Greater AF burden was, however, the only AF characteristic associated with lower QoL, when adjusted for sex, type of AF, hypertension, heart rate > 110 bpm during AF, and beta-blocker use in multiple linear regression analyses. For every 10% increase in AF burden, there was a 1.34 point decrease of Vitality score (95% confidence interval (CI)
-2.67–0.02, p=0.047). The Vitality score was 12 points lower (95% CI -22.73 – -1.27, p=0.03) in patients with an AF burden >33% (Q4) versus those with < 0.45% (Q1), but only in unadjusted analysis.