3 | RESULTS
A total of 102 OHCA patients were included in this study. The mean age of the study population was were 61.0 ± 12.5 and 72.5% of the patients were male. Of these 102 patients, 59 (57.8%) died during the hospital stay. The comparison of baseline characteristics of the survivor and non-survivor patients are listed in Table 1. It was found that the duration of ICU was significantly longer in survivor group compared to non-survivor group.
Comparison of the laboratory parameters of the study population is presented in Table 2. NLR (4.5 [3.3-5.9] vs. 2.9 [1.0-5.7], P = 0.012), CRP (6.4 [1.9-11.8] vs. 1.9 [0.8-4.5], P < 0.001), CAR (1.6 [0.5-3.3] vs. 0.5 [0.2-1.3], P < 0.001) and lactate level (7 [3.8-11.2] vs. 4.4 [2.5-7.0], P = 0.002) were significantly higher whereas lymphocyte (2.6 [1.5-3.2] vs. 3.5 [1.9-5.8], P = 0.008) and serum albumin level (3.4 ± 0.6 vs. 3.8 ± 0.4, P < 0.001) were significantly lower in non-survivor group.
The area under the curves (AUC) of CAR, CRP and albumin were compared with each other to determine whether there was an additional benefit of using CAR on CRP and albumin for predicting in-hospital mortality. The AUC of CAR was significantly higher than both the AUC of CRP (0.738 vs 0.717, P = 002) and albumin (0.738 vs. 0.611, P < 0.001) for predicting in-hospital mortality (Figure 1). CAR ≥ 4.6 predicted in-hospital mortality with a sensitivity of 64.4% and specificity of 76.7%.
Multivariate logistic regression analysis was performed to determine the independent predictors of mortality. NLR (odds ratio [OR]: 1.044, 95% confidence interval [CI]: 1.044-1.437, P = 0.013), CAR (OR: 1.971, 95% CI: 1.327-2.930, P = 0.001), and lactate level (OR: 1.268, 95% CI: 1.095-1.469, P = 0.002) were found to be the independent predictors of mortality (Table 3).