Scrub typhus in pregnancy presenting with permanent hearing loss: A case
report
Running title: scrub typhus and hearing loss
Abstract
Introduction: Scrub typhus can present with audiological symptoms.
Case: A pregnant mother presented with persistent fever, pneumonia and
hearing loss. Investigation showed positive serology for scrub typhus.
Conclusion: Clinicians must be aware of audiological presentations in
scrub typhus. Possibly, permanent hearing loss was due to
meningoencephalitis and hormone induced immunomodulation.
Keywords: hearing loss; pregnancy; scrub typhus.
Introduction
Scrub typhus is a mite borne infectious disease caused by Orientia
tsutsugamushi . The vector and reservoir for this disease is the larval
trombiculid mites also known as chiggers. The southern belt of Bhutan is
seasonally endemic to scrub typhus with highest occurrence in farmers.1
The clincal manifestations of this non specific febrile illness are
intense headache and myalgia. Some patients develop generalized
lymphadenopathy, macular or maculopapular non pruritic rashes and an
eschar. Rare and atypical presentations such as acute reversible
auditory symptoms like hearing loss, tinnitus and otalgia have been
reported. 2,3 Possible mechanism for such
presentations are immune mediated vasculitis leading to cochlear
neuroinflammation resulting from exaggerated Th1 cellular immune
response. 3,4 The severity of infection can vary from
mild symptoms to severe multiorgan failure. Mortality rates were higher
in those developing pneumonia, delirium, myocarditis and elderly
population. 5,6
The clinical diagnosis accuracy remains non specific due to largely
overlapping symptoms seen in other tropical infections like dengue,
malaria and leptospirosis. Most patients develop thrombocytopenia,
elevated hepatic enzymes and deranged renal functions. Leucopenia or
leucocytosis may develop but most patients present normal total
leucocyte count. 7
Since the audiological symptoms related to scrub typhus discussed in the
literature were transient or reversible, we hereby present this case
with permanent hearing loss in a pregnant woman following scrub typhus
infection.
Case presentation
A previously healthy 39 year old G6P5 farmer at 34 weeks gestation was
referred from Punakha District Hospital with 5 days history of fever,
headache, generalized bodyache, shortness of breath and cough. There
were no audiological, gastrointestinal or urinary symptoms. On admission
to the maternity ward, she was ill looking but conscious with tachypnea,
high grade fever and pallor. There was no cervical lymphadenopathy,
icterus, body rashes, eschar or ear infection. Her respiratory rate was
26-30/min, pulse rate of 120 beats per minute and blood pressure of
110/70 mm Hg. Cardiac auscultation revealed ejection systolic murmur at
left lower sternal edge which was probably due to hyperdynamic
circulation in anemia.. There was coarse crepitation noted in bilateral
lung fields. Abdominal examination revealed no hepatosplenomegaly.
Cardiotocograph was reassuring.
Presumptive diagnosis of community acquired pneumonia was made and
empirical treatment started with intravenous ceftriaxone and oral
erythromycin. Antenatal corticosteroid was administered as per the
hospital protocol. One unit of packed red cell was transfused.
Laboratory investigation reports showed moderate anemia (Hb 7.9gm%),
raised C-reactive protein (19.9mg/l), and mild transaminitis. Renal
function was normal. Sputum culture showed Klebsiella pneumoniaewhich was sensitive to Ciprofloxacin and resistant to Ceftriaxone. Blood
and urine culture were sterile. Dengue serology and malaria parasite
smear were negative. Chest X ray (Figure 1) showed features suggestive
of pneumonia. Echocardiogram was done to rule out cardiac causes of
febrile illness and the findings were normal.