AUTHOR CONTRIBUTIONS
A.P.L., Y.J.K. and M.L. contributed equally to this work, carried out
data analysis, data interpretation, and wrote the manuscript with
contributions from all other authors. D.L. conducted the CHO bioreactor
cultures. Y.J.K., L.Z., H.L.L., S.C. and S.Y.M. undertook sample
processing, multiomics profiling and data acquisition. K.S.A.
contributed to data analysis. N.T., S.K.N. and Y.S.H. conceived the
study and coordinated the work. N.T., T.S., X.W., E.G., A.H-M.T., X.B.,
S.K.N., D-Y.L., W.L.W.L. and Y.S.H. contributed to interpretation of the
data, and critical revision of the manuscript.