Recent Advances in Gene Therapy for Atrial Fibrillation
Running title: Yoo et al.; Gene therapy for atrial
fibrillation
Authors: Shin Yoo1†, Gail Elizabeth
Geist1, Anna Pfenniger1, Markus
Rottmann1, Rishi Arora1†
Affiliations: 1Feinberg Cardiovascular and
Renal Research Institute, Northwestern University Feinberg School of
Medicine, Chicago, IL.
Word count: 4691 words
† Addresses for Correspondence :
Rishi Arora, MD
Northwestern University-Feinberg School of Medicine
251 East Huron, Feinberg 8-503
Chicago, IL 60611
Fax: 312-926-6295; Phone: 312-503-3217
E-mail:
r-arora@northwestern.edu
Abstract :
Atrial fibrillation (AF) is the most common heart rhythm disorder in
adults and a major cause of stroke. Unfortunately, current treatments
for AF are suboptimal as they are not targeting the molecular mechanisms
underlying AF. In this regard, gene therapy is emerging as a promising
approach for mechanism-based treatment of AF. In this review, we
summarize recent advances and challenges in gene therapy for this
important cardiovascular disease.
Key words: Gene Therapy, Atrial Fibrillation