Recent Advances in Gene Therapy for Atrial Fibrillation
Running title: Yoo et al.; Gene therapy for atrial fibrillation
Authors: Shin Yoo1†, Gail Elizabeth Geist1, Anna Pfenniger1, Markus Rottmann1, Rishi Arora1†
Affiliations: 1Feinberg Cardiovascular and Renal Research Institute, Northwestern University Feinberg School of Medicine, Chicago, IL.
Word count: 4691 words
Addresses for Correspondence :
Rishi Arora, MD
Northwestern University-Feinberg School of Medicine
251 East Huron, Feinberg 8-503
Chicago, IL 60611
Fax: 312-926-6295; Phone: 312-503-3217
E-mail: r-arora@northwestern.edu
Abstract :
Atrial fibrillation (AF) is the most common heart rhythm disorder in adults and a major cause of stroke. Unfortunately, current treatments for AF are suboptimal as they are not targeting the molecular mechanisms underlying AF. In this regard, gene therapy is emerging as a promising approach for mechanism-based treatment of AF. In this review, we summarize recent advances and challenges in gene therapy for this important cardiovascular disease.
Key words: Gene Therapy, Atrial Fibrillation