Regulation of Mitochondrial activity by nanoparticles
It has been confirmed that aging and the age-dependent reduction in
organ function are associated with a decline in mitochondrial operation
(Rockstein & Brandt, 1963).
Mitochondrial mutations leaging to functional irregularity in the
processes related to the functioning of this organ in all tissues
(Table 4 ) (Cortopassi, Shibata,
Soong, & Arnheim, 1992).
In humans, the mitochondrial malfunction is related to the aging process
and can predispose humans to some age-related diseases when they reached
a significant enough level (Khrapko &
Vijg, 2009). Thus, aging is implicated by a decrease in the activity of
mitochondrial components, such as mitochondrial enzymes, particularly
citrate synthase, a reduction in respiratory capacity per mitochondria,
an increase in production of ROS (Zid et
al.), and a reduced phosphocreatine (PCr) recovery time
(Sun, Youle, & Finkel, 2016).