Cumulative enterovirus exposure
The cumulative exposure to different EV serotypes illustrates the total
number of different EVs that the child has encountered. We hypothesized
that cumulative EV exposure would protect from allergic sensitization
but found no such association (Figure 1 ). However, there was a
trend of an inverse association between cumulative number of EV
infections and allergic disease (Figure 1 ). This association
was statistically significant between the cumulative exposure to group A
EVs and cases with atopic dermatitis (OR 0.6, 95% CI 0.36-0.99,P = 0.048).