Acknowledgements
The MD simulations were partially performed using the computational resources of Cygnus provided by the Multidisciplinary Cooperative Research Program (project code: LSC) at the Center for Computational Sciences (CCS), University of Tsukuba, Japan. This work was supported in part by the Japan Agency for Medical Research and Development (AMED) (Grant No. JP20ae0101047h0001), the Japan Agency for Science and Technology (JST) CREST program (Grant No. JPMJCR20B3), and a grant-in-aid for innovative research in “Hydrogeomics” and “Biometal Sciences” (Grant Nos. 19H05047 and 20H05497) by the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.