Author Year Region Population Simple size(n) Endoscopy Devices for index test (RAC) Reference standard for H.pylori infection Prevalence of H.pylori infection(%) TP TN FP FN Sensitivity[95% CI] Specificity[95% CI]
Alaboudy A[17] 2011 Egypt Adults 390 Standard Endoscopy ·IHC testing of gastric tissues in 184 patients ·Serum H.pylori IgG antibody in 206 patients 58.7 185 22 95 2  0.99[0.96-1.00]  0.19[0.12-0.27]
Anagnostopoulos GK[18] 2007 United Kingdom Adults 95 HD Magnifying Endoscopy ·Histological tissues testing with HE and toluidine blue stain ·Histological tissues for a CLO or CLO test 27.4 26 64 5 0  1.00[0.87-1.00]  0.93[0.84-0.98]
Cho J H[19] 2013 Korea Adults 617 Standard Endoscopy ·RUT of gastric tissues ·Histological tissues testing with Giemsa stain 42 335 230 28 24  0.93[0.90-0.96]  0.89[0.85-0.93]
Garcés-Durán R[20] 2019 Spain Adults 140 HD Endoscopy ·Histological tissues testing with Giemsa stain ·IHC in negative histologic study for H.pylori ·RUT of gastric tissues 31.4 44 47 49 0  1.00[0.92-1.00]  0.49[0.39-0.59]
Gonen C[21] 2009 Turkey Adults 129 HD Magnifying Endoscopy ·Histological tissues testing with Giemsa stain ·RUT of gastric tissues ·14C-UBT 76 84 24 5 14  0.86[0.77-0.92]  0.83[0.64-0.94]
Hidaka N[22] 2010 Japan Children 87 ·Standard Endoscopy (small caliber) ·Magnifying Endoscopy in 8 patients ·UBT ·RUT ·SAT 29 25 57 5 0  1.00[0.86-1.00]  0.92[0.82-0.97]
Inui M[23] 2020 Japan Adults 576 Standard Endoscopy ·13C-UBT ·Serum H.pylori IgG antibody ·Histological tissues testing with Giemsa stain 15.3 88 144 344 0  1.00[0.96-1.00]  0.30[0.25-0.34]
Katake Y[24] 2013 Japan Adults 723 HD Endoscopy ·Serum H.pylori antibody test ·Histological tissues testing with HE and any special stains (Giemsa, Warthin‑Starry) and IHC 70.5 506 189 24 4  0.99[0.98-1.00]  0.89[0.84-0.93]
Kato T[25] 2013 Japan Adults 275 HD Endoscopy ·Histological tissues testing with HE staining ·Immunostaining in negative histologic study for H.pylori 52.7 131 60 65 9  0.94[0.88-0.97]  0.48[0.39-0.57]
Machado R S[26] 2008 Brazil Children and adolescents 99 Standard Endoscopy(paediatric) ·Histological tissues testing with HE and Giemsa stain ·RUT of gastric tissues 32.3 31 59 8 1  0.97[0.84-1.00]  0.88[0.78-0.95]
Na S[27] 2011 Korea adults 263 Standard Endoscopy ·RUT of gastric tissues 51.3 131 53 75 4  0.97[0.93-0.99] 0.41[0.33-0.50]
Nakayama Y[28] 2004 Japan Children and young adult(8-29) 52 Standard Endoscopy ·13C-UBT ·Serum H.pylori IgG antibody ·Histological tissues testing with Giemsa stain 38.5 20 29 3 0  1.00[0.83-1.00]  0.91[0.75-0.98]
Tatewaki M[29] 2010 Japan 15-71 yrs 1875 Transnasal Endoscopy ·Serum H.pylori antibody test ·Histological tissues testing with IHC stain 36.8 665 1166 19 25  0.96[0.95-0.98]  0.98[0.98-0.99]
Terao S[30] 2015 Japan Adults 743 Standard Endoscopy ·Serum H.pylori antibody test ·RUT of gastric tissues ·Histological tissues testing ·13C-UBT 60 412 21 276 34  0.92[0.90-0.95]  0.07[0.04-0.11]
Yagi K[31] 2002 Japan 14-86 yrs 557 ·Standard Endoscopy in 162 patients ·Magnifying Endoscopy in 301 patinets ·Histological tissues testing with HE and Giemsa stain ·The culture of histological tissues ·RUT of gastric tissues 69.8 381 153 15 8  0.98[0.96-0.99]  0.91[0.86-0.95]