RAC: Regular arrangement of collecting venules; H.pylori: Helicobacter
pylori; TP: True positives; TN: True negatives; FP: False positives; FN:
False negatives; HD: High Definition; IHC: Immunohistochemistry; CLO:
Campylobacter-like organism; RUT: rapid urease test; UBT: urea breath
test; SAT: stool antigen test; HE: hematoxylin-eosin.
Fig. 1 The PRISMA flow diagram of the systematic review and
meta-analysis.
Fig. 2 Sensitivity and specificity of RAC for the diagnosis of
H. pylori infection.
Fig. 3 Summary receiver operating characteristic curve of the
accuracy of RAC for the diagnosis of H. pylori infection.
Fig. 4 Fagan nomogram of RAC for the diagnosis of H. pylori
infection.
Fig. 5 Likelihood ratio scattergram of RAC for the diagnosis of
H. pylori infection.
Fig. S1 Quality assessment of the included studies.
Fig. S2 Likelihood ratios of RAC for the diagnosis of H. pylori
infection.
Fig. S3 Diagnostic odds ratio of RAC for the diagnosis of H.
pylori infection.
Fig. S4 Deeks’ funnel plot for assessing the publication bias
of RAC for the diagnosis of H. pylori infection.
Fig. S5 Univariable meta-regression and subgroup analyses for
RAC in the diagnosis of H. pylori infection. (Variable 1, Exclusion of
past Hp infection; Variable 2, A single reference standard for H.pylori
infection; Variable 3, Consecutive enrollment.)
Table S1 Detailed search strategies used in this meta-analysis
Table S2 Studies excluded in this meta-analysis according to
the PRISMA flow diagram