References
1. Rossignoli A, Clavenna A, Bonati M. Antibiotic prescription and prevalence rate in the outpatient paediatric population: analysis of surveys published during 2000-2005. European journal of clinical pharmacology. 2007;63(12):1099-106.
2. Blanca M, Mayorga C, Torres MJ, Warrington R, Romano A, Demoly P, et al. Side-chain-specific reactions to betalactams: 14 years later. Clin Exp Allergy. 2002;32(2):192-7.
3. Ceelie I, van der Starre C, Tibboel D, Stol K, Koren G, de Wildt SN. Evaluation of drug formularies for pediatric intensive care. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011;12(1):e14-9.
4. Blumenthal KG, Li Y, Banerji A, Yun BJ, Long AA, Walensky RP. The Cost of Penicillin Allergy Evaluation. J Allergy Clin Immunol Pract. 2018;6(3):1019-27.e2.
5. Gomes ER, Brockow K, Kuyucu S, Saretta F, Mori F, Blanca-Lopez N, et al. Drug hypersensitivity in children: report from the pediatric task force of the EAACI Drug Allergy Interest Group. Allergy. 2016;71(2):149-61.
6. Caubet JC, Frossard C, Fellay B, Eigenmann PA. Skin tests and in vitro allergy tests have a poor diagnostic value for benign skin rashes due to β-lactams in children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2015;26(1):80-2.
7. Tonson la Tour A, Michelet M, Eigenmann PA, Caubet JC. Natural History of Benign Nonimmediate Allergy to Beta-Lactams in Children: A Prospective Study in Retreated Patients After a Positive and a Negative Provocation Test. J Allergy Clin Immunol Pract. 2018;6(4):1321-6.
8. Atanaskovic-Markovic M, Gaeta F, Medjo B, Gavrovic-Jankulovic M, Cirkovic Velickovic T, Tmusic V, et al. Non-immediate hypersensitivity reactions to beta-lactam antibiotics in children - our 10-year experience in allergy work-up. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2016;27(5):533-8.
9. Torres MJ, Celik GE, Whitaker P, Atanaskovic-Markovic M, Barbaud A, Bircher A, et al. A EAACI drug allergy interest group survey on how European allergy specialists deal with β-lactam allergy. Allergy. 2019;74(6):1052-62.
10. Terrados S, Blanca M, Garcia J, Vega J, Torres MJ, Carmona MJ, et al. Nonimmediate reactions to betalactams: prevalence and role of the different penicillins. Allergy. 1995;50(7):563-7.
11. Blanca-Lopez N, Jimenez-Rodriguez TW, Somoza ML, Gomez E, Al-Ahmad M, Perez-Sala D, et al. Allergic reactions to penicillins and cephalosporins: diagnosis, assessment of cross-reactivity and management. Expert review of clinical immunology. 2019;15(7):707-21.
12. Blanca M, Torres MJ, Mayorga C, Perez-Inestrosa E, Suau R, Montañez MI, et al. Immediate allergic reactions to betalactams: facts and controversies. Current opinion in allergy and clinical immunology. 2004;4(4):261-6.
13. Brockow K, Ardern-Jones MR, Mockenhaupt M, Aberer W, Barbaud A, Caubet JC, et al. EAACI position paper on how to classify cutaneous manifestations of drug hypersensitivity. Allergy. 2019;74(1):14-27.
14. Fontaine C, Mayorga C, Bousquet PJ, Arnoux B, Torres MJ, Blanca M, et al. Relevance of the determination of serum-specific IgE antibodies in the diagnosis of immediate beta-lactam allergy. Allergy. 2007;62(1):47-52.
15. Vezir E, Dibek Misirlioglu E, Civelek E, Capanoglu M, Guvenir H, Ginis T, et al. Direct oral provocation tests in non-immediate mild cutaneous reactions related to beta-lactam antibiotics. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2016;27(1):50-4.
16. Ibáñez MD, Rodríguez Del Río P, Lasa EM, Joral A, Ruiz-Hornillos J, Muñoz C, et al. Prospective assessment of diagnostic tests for pediatric penicillin allergy: From clinical history to challenge tests. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2018;121(2):235-44.e3.
17. Caubet JC, Kaiser L, Lemaître B, Fellay B, Gervaix A, Eigenmann PA. The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge. J Allergy Clin Immunol. 2011;127(1):218-22.
18. Zambonino MA, Corzo JL, Muñoz C, Requena G, Ariza A, Mayorga C, et al. Diagnostic evaluation of hypersensitivity reactions to beta-lactam antibiotics in a large population of children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2014;25(1):80-7.
19. Torres MJ, Blanca M, Fernandez J, Romano A, Weck A, Aberer W, et al. Diagnosis of immediate allergic reactions to beta-lactam antibiotics. Allergy. 2003;58(10):961-72.
20. Romano A, Blanca M, Torres MJ, Bircher A, Aberer W, Brockow K, et al. Diagnosis of nonimmediate reactions to beta-lactam antibiotics. Allergy. 2004;59(11):1153-60.
21. Ponvert C, Perrin Y, Bados-Albiero A, Le Bourgeois M, Karila C, Delacourt C, et al. Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2011;22(4):411-8.
22. Kulhas Celik I, Guvenir H, Hurmuzlu S, Toyran M, Civelek E, Kocabas CN, et al. The negative predictive value of 5-day drug provocation test in nonimmediate beta-lactam allergy in children. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2020;124(5):494-9.
23. Piccorossi A, Liccioli G, Barni S, Sarti L, Giovannini M, Verrotti A, et al. Epidemiology and drug allergy results in children investigated in allergy unit of a tertiary-care paediatric hospital setting. Italian journal of pediatrics. 2020;46(1):5.
24. Lezmi G, Alrowaishdi F, Bados-Albiero A, Scheinmann P, de Blic J, Ponvert C. Non-immediate-reading skin tests and prolonged challenges in non-immediate hypersensitivity to beta-lactams in children. Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology. 2018;29(1):84-9.
25. Mori F, Cianferoni A, Barni S, Pucci N, Rossi ME, Novembre E. Amoxicillin allergy in children: five-day drug provocation test in the diagnosis of nonimmediate reactions. J Allergy Clin Immunol Pract. 2015;3(3):375-80.e1.
26. Edwards RG, Dewdney JM, Dobrzanski RJ, Lee D. Immunogenicity and allergenicity studies on two beta-lactam structures, a clavam, clavulanic acid, and a carbapenem: structure-activity relationships. Int Arch Allergy Appl Immunol. 1988;85(2):184-9.
27. Blanca-Lopez N, Perez-Alzate D, Ruano F, Garcimartin M, de la Torre V, Mayorga C, et al. Selective immediate responders to amoxicillin and clavulanic acid tolerate penicillin derivative administration after confirming the diagnosis. Allergy. 2015;70(8):1013-9.
28. Mill C, Primeau MN, Medoff E, Lejtenyi C, O’Keefe A, Netchiporouk E, et al. Assessing the Diagnostic Properties of a Graded Oral Provocation Challenge for the Diagnosis of Immediate and Nonimmediate Reactions to Amoxicillin in Children. JAMA pediatrics. 2016;170(6):e160033.
29. Torres MJ, Mayorga C, Leyva L, Guzman AE, Cornejo-García JA, Juarez C, et al. Controlled administration of penicillin to patients with a positive history but negative skin and specific serum IgE tests. Clin Exp Allergy. 2002;32(2):270-6.
30. Blanca-López N, Zapatero L, Alonso E, Torres MJ, Fuentes V, Martínez-Molero MI, et al. Skin testing and drug provocation in the diagnosis of nonimmediate reactions to aminopenicillins in children. Allergy. 2009;64(2):229-33.
31. Vila L, Garcia V, Martinez Azcona O, Pineiro L, Meijide A, Balboa V. Mild to moderate hypersensitivity reactions to beta-lactams in children: a single-centre retrospective review. BMJ paediatrics open. 2019;3(1):e000435.
Table 1. Clinical characteristics of cases with confirmed IR by DPT