Type-4 phosphodiesterase (PDE4) blockade prevents NETosis in cystic fibrosis
Running title: Phosphodiesterase 4 inhibition in cystic fibrosis
Licia Totania, Concetta Amorea, Antonio Piccolia, Giuseppe Dell’Elbaa, Angelo Di Santoa, Roberto Plebanib,c, Romina Pecce b,c, Nicola Martellia, Ida De Finoe, Serena Ranuccie, Alice Rossie, Paolo Morettid, Alessandra Bragonzie, Mario Romanob,c, Virgilio Evangelistaa
aLaboratory of Vascular Biology and Pharmacology, Fondazione Mario Negri Sud, Santa Maria Imbaro (CH);bDepartment of Medical, Oral and Biotechnological Sciences, G. D’Annunzio University of Chieti-Pescara;cCentre for Advanced Studies and Technology (CAST), G. D’Annunzio University of Chieti-Pescara; dCystic Fibrosis Centre, S. Liberatore Hospital, Atri (TE); eInfection and Cystic Fibrosis Unit, Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milano, Italy
E-mail:
totani58licia@gmail.com (L.T.); a.concetta66@hotmail.it. (C.A.); piccolicacciatore@libero.it (A.P.); giuseppedellelba@gmail.com (G.D.E.); disatangelo@gmail.com (A.D.S.); robplebani@gmail.com (R.P.); romanella712@gmail.com (R.P.), nicolamtb@libero.it (N.M.); ranucci.serena@hsr.it (S.R.); defino.ida@hsr.it (I.D.F.); rossi1.alice@hsr.it (A.R.); dr.morettipaolo@libero.it (P.M.) bragonzi.alessandra@hsr.it (A.B.), mromano@unich.it (M.R.), evangelista59gino@gmail.com. (V.E.).