Figure legends
Fig. 1. (A) Photograph taken during the patient’s initial visit, showing an ulcerative lesion measuring ∼22 mm in diameter on the right tongue margin. (B) MR image showing frontal disconnection. (C) MR image in the horizontal view. An invasive lesion showing a contrast effect with gadolinium was observed on the right tongue margin. (D) A PET scan image showing high accumulation of fluorodeoxyglucose in the right tongue margin.
Fig. 2. (A) MR image taken seven months after tongue cancer surgery. The right upper internal jugular vein lymph node had become swollen with a minor axis of ∼12 mm, and the T2-emphasized image shows a region with moderate signal intensity that included a part of the low-signal region. (B) A CT scan image taken three months after right neck dissection. The right submandibular lymph node had become swollen with a minor axis of ∼15 mm, and the boundary with the surrounding area was unclear. (C) A CT scan image taken after chemoradiotherapy. No change in the size of the right submandibular lymph node was observed, and the boundary with the surrounding area was unclear.
Fig. 3. (A) A CT scan image taken after three courses of cetuximab combination chemotherapy. The right submandibular recurrent lymph node had disappeared. (B) A CT scan image taken three months after maintenance administration of cetuximab alone was initiated. Swelling of the right submandibular lymph node was observed. (C) A CT scan image taken after six doses of nivolumab. Shrinkage of the right submandibular lymph node was observed. (D) ACT scan image taken after 14 doses of nivolumab. Significant enlargement of the right submandibular lymph node was observed. (E) A CT scan image taken after three courses of chemotherapy with cetuximab. Significant reduction of the right submandibular recurrent lymph node was observed. (F) A CT scan image taken after 52 doses of cetuximab alone. The right submandibular lymph node had disappeared.
Fig. 4. (A, B) PET scan images taken 20 months after CR was achieved. No recurrence or metastasis was observed.