Figure 4. Simulated and Experimental Comparison of Glomerulus
and Proximal Convoluted Tubule (PCT) MPS Pump Flow and Shear Stress. (A)
Measured filtrate output flow (μL/min) for different total output pump
flow (μL/min) in both simulated and experimental settings (0.25 mm ID
tubing only).
R2=1.0. (B) Shear
stress across the apical PCT (dyne-s/cm2) for
different total output pump flow (μL/min) in both simulated and
experimental settings (0.25 mm ID tubing only).
R2=1.0. (C) Scatter plot of simulated, experimental
(single inlet tubing), single-culture, and tri-culture urine output flow
under Qin= 45.3 μL/min. (D) Scatter plot of simulated,
experimental (single inlet tubing), single-culture, and tri-culture
shear stress (dyne-s/cm2) under Qin=
45.3 μL/min. (E) Assembled MPS flow validation. Line represents median.
(* Comparison of datapoints within conditional test, p<0.05,
non-parametric one-way ANOVA).