Introduction:
Angiotensin receptor blocker (ARB) induced sprue-like enteropathy is a rare adverse effect of this class of medication but is increasingly recognized as a potential side effect that clinicians should be aware. The first published cases were from the Mayo Clinic in a case series of Olmesartan induced sprue-like enteropathy. While reported clinical manifestations of these patients included abdominal pain, severe weight loss, chronic diarrhea, and severe electrolyte derangements, there was no description of cutaneous manifestations. Since that time, only one case of ARB induced sprue-like enteropathy with cutaneous manifestations has been noted and was associated with Olmesartan, specifically. Symptoms in the above cases resolved within 3-12 months of medication discontinuation. Currently sprue-like enteropathy has yet to be classified as class effect among ARBs; however, there are several cases within the literature that advocate in favor of this idea. We report a case of sprue-like enteropathy associated with losartan with a unique cutaneous manifestation.